Autologous Mesotherapy, also known as PRP (Platelet-Rich Plasma) treatment, is an innovative fertility therapy that utilizes the woman’s own blood to enhance reproductive potential. During this procedure, platelet-rich components are isolated from the blood and then injected directly into the ovaries or the endometrium.
Thanks to the high concentration of growth factors in PRP, this treatment may support ovarian rejuvenation, improve ovarian function, and stimulate follicular development. At the same time, it can enhance endometrial thickness and endometrial receptivity, creating more favorable conditions for embryo implantation and increasing the chances of success in in vitro fertilization (IVF).
When is PRP Therapy Recommended?
PRP therapy is recommended for women experiencing conception difficulties due to diminished ovarian reserve or endometrial issues. Specifically, it is applied in cases such as:
Low egg reserve or poor egg quality
Premature ovarian insufficiency (POI) or early menopause
Thin or inadequate endometrium
Recurrent Implantation Failure
Repeated failed IVF attempts
PRP (Platelet-Rich Plasma) is a promising option for women who wish to enhance their fertility, either through ovarian rejuvenation or by increasing endometrial receptivity and endometrial thickness. The use of the woman’s own blood makes it completely safe and fully personalized.
PRP fertility treatment is a modern, personalized approach in assisted reproduction that utilizes platelet-rich plasma derived from the woman’s own blood. In reproductive medicine, PRP is mainly applied in two distinct indications: endometrial PRP, aimed at improving endometrial receptivity, and ovarian PRP, aimed at supporting ovarian function in selected cases. Although both approaches begin with blood collection and processing, the method of administration, level of invasiveness, and therapeutic goals differ significantly.
The procedure includes:
How is Endometrial PRP Performed?
Endometrial PRP is a minimally invasive procedure designed to improve the thickness, quality, and receptivity of the endometrium. The process begins with drawing a small amount of blood from the patient, similar to a routine blood test. The blood is then processed using specialized centrifugation to isolate the platelet-rich plasma, which contains high concentrations of growth factors.
The prepared PRP is then infused into the uterine cavity using a thin catheter, in a procedure similar to an intrauterine insemination or a standard gynecological examination. The treatment is typically performed without anesthesia, takes only a few minutes, and allows the patient to return immediately to her daily activities.
How is Ovarian PRP Performed?
Ovarian PRP is a more specialized and invasive procedure, typically recommended for women with diminished ovarian reserve or in cases where an additional therapeutic option is considered before undergoing IVF (in vitro fertilization). As with endometrial PRP, the process starts with blood collection and preparation of platelet-rich plasma.
However, instead of being administered into the uterus, the PRP is injected directly into the ovaries under transvaginal ultrasound guidance. The procedure is performed under mild sedation, in conditions similar to egg retrieval, ensuring patient comfort and safety. The entire process usually takes 1–2 hours, does not require hospitalization, and is followed by a short recovery period.
In cases involving the endometrium, the plasma is injected intrauterinely via a thin catheter.
For ovarian rejuvenation, the plasma is precisely injected into the ovaries using transvaginal ultrasound guidance and mild sedation, similar to egg retrieval.
What are the benefits of PRP What Are the Benefits of PRP Treatment in Fertility?
The benefits of PRP fertility treatment depend on whether the application αφορά the endometrium or the ovaries. For this reason, each woman must be evaluated individually to determine the most appropriate form of treatment based on her medical history, cause of infertility, and treatment goals. PRP is not applied uniformly in all cases, but rather tailored to the specific needs of each patient.
Benefits of Endometrial PRP
Endometrial PRP is primarily used in women with thin endometrium, insufficient endometrial development, or a history of recurrent implantation failure. The goal of the treatment is to create optimal conditions within the uterus, making the endometrium more receptive to embryo transfer.
Endometrial PRP infusion may contribute to:
Improving endometrial thickness
Supporting regeneration and repair of endometrial tissue
Enhancing endometrial receptivity
Increasing the chances of embryo implantation
Better preparation for embryo transfer in an IVF cycle
For many women who have already tried other treatment approaches without the desired outcome, endometrial PRP may represent an additional, targeted option within a more personalized assisted reproduction plan.
Benefits of Ovarian PRP
Ovarian PRP mainly aims to support ovarian function in women with poor ovarian response or diminished ovarian reserve. Although response varies from case to case, this treatment has attracted interest in reproductive medicine as a complementary approach for selected patients.
Potential benefits of ovarian PRP include:
Enhancement of ovarian activity
Possible improvement in response to IVF cycles
Support of follicular development
Potential improvement in certain hormonal markers, such as AMH and FSH
Providing an additional therapeutic option for women with limited alternatives
This treatment is not suitable for all infertility cases, but it may be incorporated into a personalized treatment protocol when clinically indicated by the treating physician.
What Results Can Be Expected from Endometrial PRP and Ovarian PRP?
The expected outcomes of PRP fertility treatment are not the same for all women, as they are influenced by multiple factors, including age, cause of infertility, hormonal profile, egg quality, endometrial condition, and overall reproductive history. For this reason, PRP should always be considered as part of a comprehensive fertility strategy rather than a standalone solution.
Expected Results from Endometrial PRP
When applied to the endometrium, PRP may lead to improved endometrial development and better implantation conditions. This is particularly important for women with thin endometrium or a history of failed embryo transfers.
Potential outcomes include improved endometrial thickness, enhanced receptivity during embryo transfer, and increased chances of implantation and pregnancy in selected cases.
Expected Results from Ovarian PRP
In ovarian PRP cases, the primary goal is the potential improvement of ovarian response. In some women, improvements in follicular development or changes in hormonal markers related to ovarian function may be observed.
In certain cases, this improvement may support a subsequent IVF attempt or create better conditions for egg retrieval. Although natural conception has been reported after ovarian PRP, this is not a predictable or guaranteed outcome and should be approached with realistic medical expectations.
What You Should Know About PRP Treatment Outcomes
PRP therapy is a promising method, but its results vary significantly depending on the indication and patient profile. Therefore, proper patient selection, individualized medical evaluation, and appropriate treatment planning are critical factors.
PRP can serve as a valuable complementary tool both in preparing the endometrium and in supporting ovarian function, when integrated into a comprehensive assisted reproduction strategy.
What Does the Research Say About PRP Therapy?
Intrauterine PRP (Platelet-Rich Plasma) infusion is an innovative therapeutic approach in in vitro fertilization (IVF), aiming to improve endometrial receptivity. PRP contains growth factors such as VEGF, PDGF, TGF-β, and EGF, which enhance angiogenesis, cell regeneration, and the repair of endometrial tissue. According to clinical studies, the use of PRP may increase endometrial thickness and significantly improve implantation and pregnancy rates, particularly in women with recurrent implantation failure (RIF) or a thin endometrium.
Studies such as those by Nazari et al. (2020), Eftekhar et al. (2018), and Zamaniyan et al. (2021) reported increased pregnancy and implantation rates following PRP treatment, while more recent reviews, such as Zhao et al. (2023), confirm its positive effect. Overall, PRP appears to be a promising option for improving IVF outcomes in selected cases.
Frequently asked questions about Autologous PRP Mesotherapy
What is PRP therapy in fertility?
PRP (Platelet-Rich Plasma) is a treatment that utilizes plasma derived from the patient’s own blood, enriched with growth factors. It is used to enhance fertility by activating regenerative processes in tissues, aiming to increase the chances of embryo implantation and pregnancy.
In which cases is PRP therapy recommended?
This treatment is mainly recommended for women who have experienced recurrent implantation failure or have low success rates in IVF cycles. It may also be applied in women with a thin endometrium.
The medical team at FertUlity will guide you based on your individualized profile to determine whether PRP fertility treatment is the right option for you.
Is the procedure painful?
The experience of PRP treatment varies depending on the type of application:
Endometrial PRP:
The procedure is short and minimally invasive, usually performed without anesthesia, and causes mild discomfort similar to a gynecological ultrasound or a simple intrauterine examination. Most women tolerate it very well and can return immediately to their daily activities.
Ovarian PRP:
In contrast to intrauterine application, PRP injection into the ovaries is a more invasive procedure and is performed under sedation or light anesthesia. It is carried out transvaginally, under ultrasound guidance, and requires medical preparation similar to other assisted reproduction procedures.
How long does the therapy take?
Blood collection and processing may take between 30 minutes to 2 hours. The PRP is then applied immediately, and the application procedure itself does not exceed 30 minutes.
Are there any side effects?
Possible side effects of PRP treatment depend on the type of application:
Endometrial PRP:
Since the patient’s own blood is used, the method is considered very safe, and side effects are extremely rare. In most cases, no adverse effects are observed, although mild and temporary discomfort, similar to a gynecological examination, may occur.
Ovarian PRP:
This is a more invasive procedure, and potential side effects are similar to those of oocyte retrieval. These may include mild pain, slight bleeding, or pelvic discomfort for a short period. In all cases, the procedure is performed under medical supervision to ensure maximum safety.
When can I start IVF after PRP therapy?
Usually, IVF can begin during the same or the next cycle after the therapy, always under the guidance of the FertUlity scientific team.
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