Autologous PRP Mesotherapy A Breakthrough in Female Fertility with the Power of Plasma

What is PRP Therapy?

Autologous Mesotherapy, also known as PRP (Platelet-Rich Plasma) treatment, is an innovative fertility therapy that utilizes the woman’s own blood to enhance reproductive potential. During this procedure, platelet-rich components are isolated from the blood and then injected directly into the ovaries or the endometrium.

Thanks to the high concentration of growth factors in PRP, this treatment may support ovarian rejuvenation, improve ovarian function, and stimulate follicular development. At the same time, it can enhance endometrial thickness and endometrial receptivity, creating more favorable conditions for embryo implantation and increasing the chances of success in in vitro fertilization (IVF).

When is PRP Therapy Recommended?

PRP therapy is recommended for women experiencing conception difficulties due to diminished ovarian reserve or endometrial issues. Specifically, it is applied in cases such as:

PRP (Platelet-Rich Plasma) is a promising option for women who wish to enhance their fertility, either through ovarian rejuvenation or by increasing endometrial receptivity and endometrial thickness. The use of the woman’s own blood makes it completely safe and fully personalized.

What is the PRP Treatment Procedure?

PRP fertility treatment is a modern, personalized approach in assisted reproduction that utilizes platelet-rich plasma derived from the woman’s own blood. In reproductive medicine, PRP is mainly applied in two distinct indications: endometrial PRP, aimed at improving endometrial receptivity, and ovarian PRP, aimed at supporting ovarian function in selected cases. Although both approaches begin with blood collection and processing, the method of administration, level of invasiveness, and therapeutic goals differ significantly.

The procedure includes:

How is Endometrial PRP Performed?

Endometrial PRP is a minimally invasive procedure designed to improve the thickness, quality, and receptivity of the endometrium. The process begins with drawing a small amount of blood from the patient, similar to a routine blood test. The blood is then processed using specialized centrifugation to isolate the platelet-rich plasma, which contains high concentrations of growth factors.

The prepared PRP is then infused into the uterine cavity using a thin catheter, in a procedure similar to an intrauterine insemination or a standard gynecological examination. The treatment is typically performed without anesthesia, takes only a few minutes, and allows the patient to return immediately to her daily activities.

How is Ovarian PRP Performed?

Ovarian PRP is a more specialized and invasive procedure, typically recommended for women with diminished ovarian reserve or in cases where an additional therapeutic option is considered before undergoing IVF (in vitro fertilization). As with endometrial PRP, the process starts with blood collection and preparation of platelet-rich plasma.

However, instead of being administered into the uterus, the PRP is injected directly into the ovaries under transvaginal ultrasound guidance. The procedure is performed under mild sedation, in conditions similar to egg retrieval, ensuring patient comfort and safety. The entire process usually takes 1–2 hours, does not require hospitalization, and is followed by a short recovery period.

In cases involving the endometrium, the plasma is injected intrauterinely via a thin catheter.

For ovarian rejuvenation, the plasma is precisely injected into the ovaries using transvaginal ultrasound guidance and mild sedation, similar to egg retrieval.

What are the benefits of PRP What Are the Benefits of PRP Treatment in Fertility?

The benefits of PRP fertility treatment depend on whether the application αφορά the endometrium or the ovaries. For this reason, each woman must be evaluated individually to determine the most appropriate form of treatment based on her medical history, cause of infertility, and treatment goals. PRP is not applied uniformly in all cases, but rather tailored to the specific needs of each patient.

Benefits of Endometrial PRP

Endometrial PRP is primarily used in women with thin endometrium, insufficient endometrial development, or a history of recurrent implantation failure. The goal of the treatment is to create optimal conditions within the uterus, making the endometrium more receptive to embryo transfer.

Endometrial PRP infusion may contribute to:

Improving endometrial thickness

Supporting regeneration and repair of endometrial tissue

Enhancing endometrial receptivity

Increasing the chances of embryo implantation

Better preparation for embryo transfer in an IVF cycle

For many women who have already tried other treatment approaches without the desired outcome, endometrial PRP may represent an additional, targeted option within a more personalized assisted reproduction plan.

Benefits of Ovarian PRP

Ovarian PRP mainly aims to support ovarian function in women with poor ovarian response or diminished ovarian reserve. Although response varies from case to case, this treatment has attracted interest in reproductive medicine as a complementary approach for selected patients.

Potential benefits of ovarian PRP include:

Enhancement of ovarian activity

Possible improvement in response to IVF cycles

Support of follicular development

Potential improvement in certain hormonal markers, such as AMH and FSH

Providing an additional therapeutic option for women with limited alternatives

This treatment is not suitable for all infertility cases, but it may be incorporated into a personalized treatment protocol when clinically indicated by the treating physician.

What Results Can Be Expected from Endometrial PRP and Ovarian PRP?

The expected outcomes of PRP fertility treatment are not the same for all women, as they are influenced by multiple factors, including age, cause of infertility, hormonal profile, egg quality, endometrial condition, and overall reproductive history. For this reason, PRP should always be considered as part of a comprehensive fertility strategy rather than a standalone solution.

Expected Results from Endometrial PRP

When applied to the endometrium, PRP may lead to improved endometrial development and better implantation conditions. This is particularly important for women with thin endometrium or a history of failed embryo transfers.

Potential outcomes include improved endometrial thickness, enhanced receptivity during embryo transfer, and increased chances of implantation and pregnancy in selected cases.

Expected Results from Ovarian PRP

In ovarian PRP cases, the primary goal is the potential improvement of ovarian response. In some women, improvements in follicular development or changes in hormonal markers related to ovarian function may be observed.

In certain cases, this improvement may support a subsequent IVF attempt or create better conditions for egg retrieval. Although natural conception has been reported after ovarian PRP, this is not a predictable or guaranteed outcome and should be approached with realistic medical expectations.

What You Should Know About PRP Treatment Outcomes

PRP therapy is a promising method, but its results vary significantly depending on the indication and patient profile. Therefore, proper patient selection, individualized medical evaluation, and appropriate treatment planning are critical factors.

PRP can serve as a valuable complementary tool both in preparing the endometrium and in supporting ovarian function, when integrated into a comprehensive assisted reproduction strategy.

What Does the Research Say About PRP Therapy?

Intrauterine PRP (Platelet-Rich Plasma) infusion is an innovative therapeutic approach in in vitro fertilization (IVF), aiming to improve endometrial receptivity. PRP contains growth factors such as VEGF, PDGF, TGF-β, and EGF, which enhance angiogenesis, cell regeneration, and the repair of endometrial tissue. According to clinical studies, the use of PRP may increase endometrial thickness and significantly improve implantation and pregnancy rates, particularly in women with recurrent implantation failure (RIF) or a thin endometrium.

Studies such as those by Nazari et al. (2020), Eftekhar et al. (2018), and Zamaniyan et al. (2021) reported increased pregnancy and implantation rates following PRP treatment, while more recent reviews, such as Zhao et al. (2023), confirm its positive effect. Overall, PRP appears to be a promising option for improving IVF outcomes in selected cases.

Frequently asked questions about Autologous PRP Mesotherapy

What is PRP therapy in fertility?

PRP (Platelet-Rich Plasma) is a treatment that utilizes plasma derived from the patient’s own blood, enriched with growth factors. It is used to enhance fertility by activating regenerative processes in tissues, aiming to increase the chances of embryo implantation and pregnancy.

In which cases is PRP therapy recommended?

This treatment is mainly recommended for women who have experienced recurrent implantation failure or have low success rates in IVF cycles. It may also be applied in women with a thin endometrium.

The medical team at FertUlity will guide you based on your individualized profile to determine whether PRP fertility treatment is the right option for you.

Is the procedure painful?

The experience of PRP treatment varies depending on the type of application:

Endometrial PRP:

The procedure is short and minimally invasive, usually performed without anesthesia, and causes mild discomfort similar to a gynecological ultrasound or a simple intrauterine examination. Most women tolerate it very well and can return immediately to their daily activities.

Ovarian PRP:

In contrast to intrauterine application, PRP injection into the ovaries is a more invasive procedure and is performed under sedation or light anesthesia. It is carried out transvaginally, under ultrasound guidance, and requires medical preparation similar to other assisted reproduction procedures.

How long does the therapy take?

Blood collection and processing may take between 30 minutes to 2 hours. The PRP is then applied immediately, and the application procedure itself does not exceed 30 minutes.

Are there any side effects?

Possible side effects of PRP treatment depend on the type of application:

Endometrial PRP:

Since the patient’s own blood is used, the method is considered very safe, and side effects are extremely rare. In most cases, no adverse effects are observed, although mild and temporary discomfort, similar to a gynecological examination, may occur.

Ovarian PRP:

This is a more invasive procedure, and potential side effects are similar to those of oocyte retrieval. These may include mild pain, slight bleeding, or pelvic discomfort for a short period. In all cases, the procedure is performed under medical supervision to ensure maximum safety.

When can I start IVF after PRP therapy?

Usually, IVF can begin during the same or the next cycle after the therapy, always under the guidance of the FertUlity scientific team.

Our Doctors

In an era where fertility requires knowledge, care, and substantial guidance, FertUlity is not an impersonal clinic. It is two people who look you in the eye and accompany you step by step on the journey you dream of.

Dr. Chrysostomos (Makis) Papadopoulos Obstetrician – Gynecologist, MD, PhDc, MIC I

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Dr. Chrysostomos Papadopoulos - Specialist in Infertility, Endocrinology & Menopause in Athens

Dr. Maria Oikonomou Obstetrician – Gynecologist

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FertulityThrough the Words of our Parents

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      EXCELLENT  
   Based on 12 reviews 
    
 
 
 
   
 
 
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   Μαρια 
 26 days ago
 
 
  The word "thank you" to Dr. Makis Papadopoulos is too small to describe the gratitude we feel for this man. I am pregnant after IVF, having succeeded on the first attempt, and we owe this exclusively to our doctor. First Contact & Communication: From the very first contact, he won us over with his kindness, enthusiasm and willingness to dedicate as much time as we needed. Willing to explain everything in every detail, he solved every question we had in depth — not even a professor to students would analyze them with such patience and contagiousness! Scientific Training: He is an excellent scientist, with deep knowledge of the subject, a perfectionist and focused professional who leaves absolutely nothing to chance. He designed the right treatment for us, solving every problem down to the last detail, making us feel that whatever problem arises, it is certain that it will be solved. HUMANITY & SUPPORT: The most important thing, however, is his humanity. Communication with him was Immediate and he always had as much time as you needed on the phone to solve every question. He showed a deep, real interest, embracing us not just as a doctor, but as if he were our brother. We highly recommend him to every couple starting this journey. He deserves blind trust! We thank you from the bottom of our hearts for the greatest miracle of our lives!

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   Alexandra 
 52 days ago
 
 
  I don't often write reviews, but I feel that Mr. Makis truly deserves it. From the very first moment, he made me feel safe and confident. He listened carefully to what was on my mind, answered every question I had, and explained everything in a simple way, always based on scientific data. Many times, he even sent me relevant scientific studies so that I could better understand why he was suggesting a particular approach. But what stood out to me the most was that he didn't stop at the appointment. He followed up, was genuinely interested in my progress, and was available when I needed him. This is something you rarely encounter. Fortunately, he returned to Greece. He is one of the few doctors who, beyond their knowledge, remain above all human beings. He makes you feel like he sees you as a person and not as just another incident.

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   Matina 
 69 days ago
 
 
  A big thank you to Dr. Makis Papadopoulos who supported us from day one, who checked every little detail, who explained to us every move-step, every test, every medication for the reason we were doing it and what we would achieve. With incredible experience, knowledge, a lot of patience (because we had two other failed attempts with another doctor) and trust, within 8 months he adapted the protocols for our case and we achieved the positive result and we hold in our arms a priceless diamond. Above all, a rare person, calm and always available to listen to our concerns and reassure us. I highly recommend him!

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   Eva 
 93 days ago
 
 
  Thanks to Dr Makis Papadopoulos, I am now holding my two beautiful babies in my arms! He is a true expert. Professional with a human centric approach, friendly and empathetic, always available to answer our (many many) questions. I trust Dr Makis blindly and, honestly, I cannot recommend him enough!
  
 
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   Ivy 
 100 days ago
 
 
  My experience with Dr. Makis took me from a clinical stagnation to an incredible breakthrough, highly recommend Dr. Makis! Navigating the exhausting world of IVF, you know how devastating it is to watch your protocol dosages go up while your results go down. After three intense, high-dosage cycles with a previous clinic, I was left feeling incredibly discouraged. Despite escalating medications and growth hormones, my blastocyst yield was dwindling, culminating in a heartbreaking round with zero blastocysts. I knew I needed a doctor who didn't just follow a standard script, but who truly understood the nuances of egg quality and customized protocols. That is when I found Dr. Makis. Dr. Makis completely revolutionized my treatment plan. Instead of just pushing maximum dosages, he took a highly strategic, tailored approach. The result? Quality over pure protocol size. While my previous doctors kept increasing the medication dosages (which yielded fewer or zero blastocysts), Dr. Makis completely changed the strategy. He lowered the heavy stimulation, introduced smart egg-quality support (like melatonin), changed the protocol style entirely, and achieved a 700% increase in blastocysts compared to my best previous rounds. Beyond the incredible results, Dr. Makis brings a level of expertise, precision, and reassuring care that is rare to find. He looks at you as an individual, not a statistic, and knows exactly how to pivot when traditional routes fail. If you are looking for a specialist who can turn a difficult prognosis into an overwhelming success, look no further than Dr. Makis. I am incredibly grateful for his care.
  
 
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   Olga 
 111 days ago
 
 
  Dr. Makis Papadopoulos was excellent, professional, and very reassuring throughout the entire process. Thanks to his expertise and guidance, we were able to identify the issue early and take the appropriate steps from the beginning. He took the time to explain everything clearly, answered all our questions with patience, and made us feel comfortable and confident throughout our journey. We truly appreciated his caring approach, professionalism, and dedication. Highly recommended!
  
 
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   Euaggelia 
 122 days ago
 
 
  Dr. Makis Papadopoulos is an excellent scientist and above all a rare person! He is an approachable and smiling doctor, with excellent medical knowledge, who from the first moment I met him made me feel comfortable and trust him completely, answering every question I had with patience and documenting every answer with scientific studies and articles! The most important thing, however, is that Dr. Makis Papadopoulos is always there on the other end of the line to listen to you and reassure you without a trace of haste, a doctor who truly cares and makes you feel like he is your own person! Makis, thank you very much for everything!!! I am very lucky to have met you!

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   Anastasia 
 129 days ago
 
 
  Dr. Makis Papadopoulos is an excellent scientist with a human-centered interest. Our collaboration was excellent from the very beginning and he made me feel confident and secure by explaining every step of the process in great detail. I highly recommend him!

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   Fay 
 131 days ago
 
 
  Dr Makis Papadopoulos is very professional, caring and attentive. Very thorough in explaining the whole process throughout every step. Thank you! Highly recommended!!
  
 
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   Christina 
 134 days ago
 
 
  I would like to share my experience with Dr. Makis Papadopoulos, an outstanding gynecologist and scientist. We first connected in the summer of 2024, while he was based in Germany, through a mutual acquaintance, following a particularly challenging period for us. Prior to meeting him, we had gone through repeated unsuccessful attempts of stimulation and fertilization with other gynecologists. Unfortunately, those approaches relied largely on standardized protocols, without sufficient personalization to address the specific needs of my case. From the very beginning, Dr. Makis stood out for his human-centered approach and his willingness to dedicate time to truly understand our situation in depth. With strong, up-to-date scientific knowledge, he approaches every case holistically, focusing on individualized treatment and adapting protocols to the patient's unique needs. Throughout our collaboration, which now spans approximately two years (with a few breaks on our side), he has consistently been available, supportive, and clear in his guidance. He inspired confidence and helped us stay positive even during difficult phases of the journey. Beyond his scientific expertise, what truly sets him apart is his genuine care for the person behind each case: his empathy, honesty, and continuous effort to achieve the best possible outcome. My husband and I are deeply grateful for his support and guidance, and we now feel ready and optimistic to move forward to the next final stage. We highly recommend him to anyone seeking a gynecologist with true expertise, professionalism, and compassion. I would like to share my experience with Dr. Makis Papadopoulos, an excellent gynecologist and scientist. We met in the summer of 2024, when he was in Germany, through a mutual acquaintance, after a particularly demanding period for us. Before meeting him, we had gone through repeated failed attempts at stimulation and fertilization with other gynecologists. Unfortunately, the approaches that had been followed were mainly based on standardized protocols, without the necessary individualization to the specifics of my case. From the beginning, Dr. Makis stood out for his human approach and his willingness to spend time to understand our case in depth. With modern knowledge and scientific training, he approaches each issue multidimensionally, emphasizing the individualization of treatment and adapting the protocols to the real needs of the patient. During our collaboration, which now spans about two years (with short breaks on our part), he was always available, supportive and clear in his guidance. He inspired confidence in us and helped us remain optimistic even in difficult phases. In addition to his scientific competence, what sets him apart is his genuine interest in the person behind each case: his empathy, his honesty and his constant effort to achieve the best possible outcome. My husband and I thank him warmly for his support and guidance and we now feel ready and optimistic to move on to the next final stage. We highly recommend him to anyone looking for a gynecologist with real knowledge, professionalism and humanity.

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   Faidra 
 135 days ago
 
 
  Dr. Makis Papadopoulos is an excellent gynecologist and above all an excellent person! I truly thank him for his support and care during the egg freezing process. Although my case was particularly demanding, he stood by me with patience, knowledge, great experience and real interest. Our communication was direct and human, while his availability at the many appointments made me feel safe at every step. The protocols were designed specifically for me, aiming for the best possible result, while also taking into account the cost of the medications. I recommend him with all my heart to every woman who wants to trust someone for something so important and sensitive for her.

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   Iliana 
 137 days ago
 
 
  I highly recommend Dr. Makis, he is an incredible specialist. My journey was far from easy, encountering several challenges that  made the process feel overwhelming at times. What sets him apart is his willingness to go beyond standard procedures. He developed a specialized, custom protocol, tailored to my situation, which ultimately made all the difference. Beyond his technical expertise, his calm and clear communication kept me grounded throughout the process. I am so grateful for his persistence and high level of care!

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