



| Criterion | ICSI | IMSI | PICSI |
|---|---|---|---|
| Full Name | Intracytoplasmic Sperm Injection | Intracytoplasmic Morphologically Selected Sperm Injection | Physiological Intracytoplasmic Sperm Injection |
| Main Difference | A single sperm cell is injected into the egg without advanced sperm selection techniques. | High-magnification morphological sperm analysis | Sperm selected by binding to hyaluronic acid |
| Selection Type | Based on motility & basic morphology | Based on detailed head & acrosomal structure | Based on natural maturation & function |
| Benefit | Bypasses male fertility issues | Better sperm selection in cases of poor morphology | Minimizes DNA fragmentation – ensures sperm maturity |
| Recommended For | Cases of low sperm count, reduced sperm motility, or abnormal sperm morphology. | Repeated implantation failures / poor morphology | Low HBA, high DFI, IVF failures |

