Fertulity IVF
Fertulity IVF

Endometriosis & Fertility

Endometriosis is one of the most common yet often overlooked causes of infertility, significantly affecting a woman’s ability to conceive naturally. If you are experiencing symptoms or have been diagnosed and are seeking solutions for endometriosis and fertility, there are now specialized methods and treatments that can improve your chances of conception—even in advanced stages of the condition.

What Is Endometriosis?

Endometriosis is a chronic, inflammatory gynecological condition characterized by the presence of endometrial tissue – that is, tissue similar to the one that normally lines the inside of the uterus – in areas outside the uterus, such as the ovaries, fallopian tubes, peritoneum, and even the intestines or bladder. This ectopic tissue is affected by hormonal changes of the menstrual cycle and reacts like endometrial tissue: it thickens, bleeds, and causes inflammation, creating adhesions, cysts, and scarring in nearby tissues.

The disease can be present even without pronounced symptoms, making diagnosis difficult and often delayed. However, many women experience severe pelvic pain, especially during menstruation, pain during intercourse, menstrual irregularities, gastrointestinal symptoms, or fertility problems.

Endometriosis is not just a “bothersome” condition; it can have a profound impact on a woman’s physical and psychological health, especially when associated with conception difficulties. It is estimated that approximately 30% to 50% of women with endometriosis have difficulty achieving pregnancy. Early diagnosis and correctly personalized treatment can significantly improve both quality of life and the chances of pregnancy,

Symptoms & Diagnosis

Endometriosis may manifest in different ways depending on its severity and location. In some cases, it is entirely asymptomatic, while in others it causes intense pain and affects a woman's daily life and fertility. Recognizing the symptoms and obtaining the correct diagnosis is crucial for choosing the appropriate treatment approach.

Main Symptoms

Severe menstrual pain (dysmenorrhea)
Pain during sexual intercourse (dyspareunia)
Chronic pelvic pain
Irregular menstrual cycles or bleeding between periods
Constipation or diarrhea, especially around menstruation
Discomfort during urination or bowel movements
Fatigue and a general sense of discomfort
Difficulty conceiving or infertility
Symptoms are often misinterpreted or considered normal, leading to delayed diagnosis, which may exceed even 7 years from symptom onset.

Examinations (Ultrasound, Laparoscopy)

Diagnosis of endometriosis is based on a combination of medical history, clinical examination, and specialized imaging techniques:

Transvaginal Ultrasound (TVUS)

Helps identify endometriotic cysts in the ovaries (endometriomas) but has limitations in visualizing lesions in other areas.

Magnetic Resonance Imaging (MRI)

Useful for detecting deep infiltrating endometriosis, especially in the intestines or bladder.

Laparoscopy (diagnostic):

The gold standard in diagnosis, allowing direct visualization and biopsy of lesions. The procedure is performed under general anesthesia and has both diagnostic and therapeutic value. Early recognition of symptoms combined with specialized diagnostic testing leads to timely intervention, reducing the impact of endometriosis on fertility and a woman’s quality of life.
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How Does It Affect Fertility?

Endometriosis affects fertility through various mechanisms that alter the anatomy of the pelvis as well as the function of the ovaries, fallopian tubes, and endometrium. Even in mild forms, the condition can reduce natural conception chances, making medical intervention necessary.

Decreased Conception Rate (15% vs 30%)

According to scientific data, women with endometriosis have about a 15% chance of conceiving naturally, compared to 30% in women without the condition, within one year of regular intercourse. This rate is influenced by the degree of endometriosis, the woman’s age, and other factors such as the presence of adhesions or ovarian cysts. In advanced stages, anatomical distortion of the pelvis and dysfunction in the fallopian tubes hinder natural fertilization.

Egg Quality & Inflammation

The chronic inflammation caused by endometriosis creates a toxic microenvironment around the ovaries, directly affecting egg quality and ovarian tissue function. Inflammatory factors such as prostaglandins and cytokines alter folliculogenesis physiology and reduce the egg’s ability to be fertilized. Moreover, endometriosis can also affect endometrial receptivity, lowering the chances of successful embryo implantation. Assisted reproductive techniques, such as IVF, offer meaningful solutions, especially when accompanied by proper preparation and individualized management.
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Modern Treatments for Endometriosis

Management of endometriosis depends on age, stage of the disease, symptom severity, and—above all—the desire for childbearing. Modern treatments for endometriosis combine pharmaceutical options, minimally invasive surgical methods, and, when required, assisted reproductive techniques such as in vitro fertilization (IVF). The goal is symptom relief, preservation of fertility, and restoration of quality of life.

Medications

Surgical Removal (Laparoscopy / Robotic)

Medical treatment aims mainly at suppressing ovulation and hormonal effects that worsen endometriosis symptoms. The most common options are listed below:
Category Advantages Disadvantages
Birth control pills (combined or progestin-only) Regulate cycle, reduce symptoms Do not cure disease, side effects
Progestins (Dienogest, Medroxyprogesterone) Suppress endometriotic activity May cause bleeding and weight fluctuations
GnRH analogues (agonists/antagonists) Strong suppression of lesions Menopausal side effects, limited duration
NSAIDs Pain relief Do not affect disease progression
Surgical treatment of endometriosis involves removal or cauterization of endometriotic lesions using laparoscopy or robot-assisted laparoscopy. This procedure has both diagnostic and therapeutic value and significantly improves natural conception rates, especially in women with mild to moderate endometriosis.
The main advantages of the minimally invasive approach include:
Precise mapping and removal of endometriotic lesions
Preservation of fertility and ovarian function
Significant reduction of pelvic pain
Fast recovery and minimal incision
Robotic surgery offers even greater precision and minimizes trauma to healthy tissues, which is particularly important in women trying to conceive. In many cases, surgical treatment is combined with medication or precedes IVF to increase fertilization success rates. Choosing the right treatment is individualized and based on collaboration with a specialized medical team.

IVF & Other Assisted Reproductive Techniques

Endometriosis can make natural conception difficult or even impossible, especially when it affects the fallopian tubes, ovaries, or endometrial receptivity. Modern assisted reproductive techniques, with IVF as the main method, offer meaningful solutions for couples struggling with endometriosis-related infertility. Through careful medical evaluation and personalized treatment protocols, conception chances can increase significantly.

When to Choose IVF

IVF is usually recommended in the following cases:
When endometriosis is severe (stage III–IV) and extensive adhesions or cysts have formed
When medical or surgical treatment has not led to pregnancy
When a coexisting infertility factor is present (e.g., low sperm count/motility)
When the woman is over 35 and has low ovarian reserve
When waiting time for natural conception exceeds 6–12 months without success
IVF bypasses certain barriers created by endometriosis, such as disrupted fallopian tube function or reduced egg motility.

Mitochondrial Replacement Therapy (MRT) – Clinical Trials in Greece

Mitochondrial replacement therapy (MRT) is an innovative technique used in selected cases of women with severe egg dysfunction, often due to endometriosis or age-related decline. This method combines the mother’s genetic material with healthy donor mitochondria, improving egg energy output and increasing chances of successful fertilization and implantation. In Greece, controlled MRT clinical trials have already begun in selected assisted reproduction centers, with encouraging initial results. This technique is not indicated for all cases, but it opens new possibilities for women with infertility resistant to conventional IVF. These developments highlight the importance of access to specialized clinics and scientific teams that implement the most advanced reproductive protocols with the goal of personalized success.
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Endometriosis & Fertility

How long does it take to diagnose endometriosis?

Diagnosis of endometriosis can be delayed 5 to 10 years, as symptoms are often misinterpreted or attributed to other conditions such as irritable bowel syndrome or painful periods.

Can there be endometriosis without pain or symptoms?

Yes, many women have endometriosis without any apparent symptoms. Infertility may be the only symptom that leads to diagnosis.

How does endometriosis affect the fallopian tubes?

Endometriosis can cause adhesions around the fallopian tubes, restricting their movement and obstructing natural fertilization.

Can I conceive naturally with mild endometriosis?

Yes, many women with mild endometriosis conceive naturally, especially if there are no other infertility factors and if the tubes remain functional.

How much does age affect IVF success with endometriosis?

Age is a decisive factor. Women under 35 have significantly higher success rates, even with endometriosis, compared to older women.

Can diet affect endometriosis symptoms?

Yes, anti-inflammatory dietary approaches (e.g., reduced processed foods, sugar, and red meat) may help reduce symptoms.

Is there a risk of recurrence after surgery?

There is a possibility of recurrence, especially if no appropriate hormonal or supportive treatment follows surgery. Choosing the right protocol significantly reduces this risk.

Can egg freezing be done in women with endometriosis?

Yes, egg freezing is particularly recommended for women with endometriosis, as the condition may negatively impact ovarian reserve over time.

Does endometriosis affect the course of pregnancy?

In most cases, once pregnancy is achieved, symptoms of endometriosis subside. However, in some cases there may be an increased risk of miscarriage or complications depending on disease severity.

What alternative treatments are used for endometriosis?

Some women try complementary approaches like acupuncture, pelvic floor physiotherapy, or psychotherapy for chronic pain management. These do not replace medical treatment but can serve as supportive options.

Our Doctors

In an era where fertility requires knowledge, care, and substantial guidance, FertUlity is not an impersonal clinic. It is two people who look you in the eye and accompany you step by step on the journey you dream of.

Dr. Maria Oikonomou Obstetrician – Gynecologist

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Dr. Chrysostomos (Makis) Papadopoulos Obstetrician – Gynecologist, MD, PhDc, MIC I

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