Autologous Mesotherapy, also known as PRP (Platelet-Rich Plasma), is an innovative, natural, and non-invasive treatment that uses the woman’s own blood to enhance fertility. Through this process, the blood’s platelet-rich components are isolated and then directly injected into the ovaries or endometrium.Thanks to the growth factors contained in PRP, the therapy can rejuvenate and improve ovarian function, stimulate follicle development, and enhance endometrial quality — creating more favorable conditions for embryo implantation and increasing the success rate of in vitro fertilization (IVF).
PRP therapy is recommended for women experiencing conception difficulties due to diminished ovarian reserve or endometrial issues. Specifically, it is applied in cases such as:
Low egg reserve or poor egg quality
Premature ovarian insufficiency (POI) or early menopause
Thin or inadequate endometrium
Approaching or entering menopause
Repeated failed IVF attempts
Preparation for an IVF cycle with donor eggs
PRP is a promising option for women seeking a natural fertility boost without aggressive hormonal treatments. Since it uses the woman’s own blood, it is completely safe and fully personalized.
The PRP method is simple, quick, and painless — completed in just a few steps in a single day.
The procedure includes:
Blood Collection
Just like a regular blood draw, a small amount of blood is collected from the woman.
Blood Processing
The blood is placed in a specialized centrifuge, where the plasma rich in platelets (PRP) is separated from the other components.
PRP Injections
In cases involving the endometrium, the plasma is injected intrauterinely via a thin catheter.
For ovarian rejuvenation, the plasma is precisely injected into the ovaries using transvaginal ultrasound guidance and mild sedation, similar to egg retrieval.
The entire process takes about 1–2 hours, requires no hospitalization, and the patient can return to daily life immediately.
The PRP method offers a range of important benefits for female fertility, especially in cases where traditional treatments fall short:
Improvement of ovarian function to increase egg production and quality
Regeneration of the endometrium, especially in cases of insufficient thickness
Natural therapy without medications or hormonal drugs
Minimally invasive procedure with fast recovery
Suitable for women who have exhausted alternative options
Expected Results
PRP therapy results vary depending on the clinical case, but many women have reported:
Increase in AMH (Anti-Müllerian Hormone) levels and reduction in FSH (Follicle-Stimulating Hormone) levels — both key fertility indicators
Follicle development during IVF cycles
Higher likelihood of embryo implantation
Successful pregnancy in women with a history of failures
Moreover, there are cases where restored ovarian function led to natural conception. While this is not the case for all, it offers hope to women seeking a more natural path to motherhood.
What Does the Research Say About PRP Therapy?
PRP therapy has emerged as a viable option for women who struggle to conceive, even after multiple failed attempts. Recent studies report that PRP application can significantly increase success rates, with clinical pregnancy observed in 48% to 52% of women with implantation failure history, and embryo implantation rates reaching 40%. In some cases, improved ovarian function after PRP therapy led to natural conception — even without IVF.
Frequently asked questions about Autologous PRP Mesotherapy
What is PRP therapy in fertility?
PRP (Platelet-Rich Plasma) is a therapy that uses plasma derived from the patient’s own blood, enriched with growth factors. It is applied to naturally enhance fertility by activating regenerative processes in the tissues involved in implantation and pregnancy.
In which cases is PRP therapy recommended?
This therapy is mainly recommended for women who have experienced repeated implantation failures or have low success rates in IVF cycles. It may also be applied in cases of thin endometrium or a history of miscarriages, depending on the overall clinical profile. The FertUlity medical team will guide you based on your personalized profile to assess whether PRP fertility therapy is the right option for you.
Is the procedure painful?
The procedure is brief and minimally invasive. It is usually performed without anesthesia and causes only mild discomfort, similar to what a woman feels during a gynecological ultrasound or hysterosalpingography.
How long does the therapy take?
Blood collection and processing take about 20–30 minutes. The PRP application follows immediately, and the entire process does not exceed one hour.
Are there any side effects?
Since the patient’s own blood is used, the chances of side effects are extremely low. Mild discomfort or minor irritation may occur but resolves quickly.
When can I start IVF after PRP therapy?
Usually, IVF can begin during the same or the next cycle after the therapy, always under the guidance of the FertUlity scientific team.
Our Doctors
In an era where fertility requires knowledge, care, and substantial guidance, FertUlity is not an impersonal clinic. It is two people who look you in the eye and accompany you step by step on the journey you dream of.
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At FertUlity, we provide science-based fertility care with a human approach. We support every path, from fertility assessment and preservation to modern assisted reproduction.
