The path to parenthood can be challenging for some couples — not due to obvious factors, but because of unseen barriers like thrombophilia. Although this may be an unfamiliar term to many, its importance in achieving and maintaining a successful pregnancy is crucial. Prevention, accurate diagnosis, and specialized care are the foundation upon which we build successful pregnancies at FertUlity.
Thrombophilia is a disorder that makes the blood more prone to forming clots — blood accumulations that form when blood coagulates normally to stop bleeding. Clots become dangerous when they form without injury or stay where they shouldn't.
In the general population, symptoms may never appear. However, in reproductive medicine, the presence of a thrombophilic disorder can dramatically alter the course of a pregnancy — especially when it causes implantation failure, recurrent miscarriage, or endometrial complications. Thrombophilia must be approached with precision and scientific rigor, as its diagnosis can prevent pregnancy loss and create optimal conditions for a healthy pregnancy.
The presence of thrombophilia doesn’t necessarily mean that a pregnancy will fail. However, in some cases, it must be systematically investigated. Specifically, attention is paid in cases of:
Recurrent miscarriages, especially in the first trimester
Unexplained intrauterine growth restriction
Implantation failure in IVF treatments
Personal or immediate family history of thrombotic events
Proteinuria or pregnancy-induced hypertension in a previous pregnancy
Autoimmune diseases such as lupus or Sjögren’s syndrome
Which Tests Are Performed and How
Thrombophilia disorders are classified as inherited or acquired. The most well-known acquired form is antiphospholipid syndrome (APS), which is associated with a high rate of miscarriages.
Factor V Leiden, prothrombin mutation G20210A, antithrombin III, protein S, MTHFR mutations
Testing is done via a simple blood draw at a specialized laboratory and does not require hospitalization. If there is a strong suspicion or relevant history, test results are always interpreted in collaboration between a hematologist and a gynecologist to ensure a comprehensive approach.
What the Therapeutic Approach Is
Managing thrombophilia is a personalized process. Treatment depends both on the type of thrombophilic disorder and the woman’s medical history, especially if there have been past miscarriages or pregnancy complications.
In cases of inherited thrombophilia or antiphospholipid syndrome, preventative treatment usually involves low-molecular-weight heparin, which reduces clot formation, and a low dose of aspirin, which improves placental blood flow and provides complementary support. This therapy may begin during conception attempts or after pregnancy is confirmed and typically continues into the final weeks of pregnancy.
At the same time, close monitoring through bloodwork and ultrasounds ensures proper placental blood supply and healthy fetal development. In more complex cases — or when thrombophilia coexists with other underlying conditions — specialized treatments or dosage adjustments may be added, always under medical supervision.
The main goal is not merely to prevent complications, but to create the ideal endometrial environment for pregnancy to begin and progress safely to term.
Thrombofilia Frequently Asked Questions about Thrombophilia
Can thrombophilia be hidden?
Yes. Many women live with thrombophilia without any symptoms until miscarriage or pregnancy complications arise — such as placental abruption or intrauterine growth restriction. That’s why many seek answers only after experiencing one or more pregnancy losses.
Is thrombophilia hereditary?
Some types of thrombophilia are indeed inherited. These are genetic mutations passed from parent to child, such as Factor V Leiden, the prothrombin mutation (G20210A), or deficiencies in antithrombin, protein S, or protein C. If there’s a family history of thrombosis or miscarriage, genetic screening is recommended.
If thrombophilia is diagnosed, can I still have a successful pregnancy?
Absolutely! Thrombophilia doesn’t mean you can’t have a child — it means special preparation and monitoring are needed. With proper preventive therapy and regular checkups, most women complete their pregnancies successfully.
What is antiphospholipid syndrome?
It is an autoimmune disorder in which the immune system produces antibodies against phospholipids — substances crucial for blood clotting. These antibodies can cause microthrombi in the placenta, affecting fetal development and increasing the risk of miscarriage.
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Why choose FertUlity?
Because here, IVF is not just a medical procedure. It is a personal matter.
At FertUlity, we believe that every couple deserves to feel secure, respected and hopeful. We combine expertise in reproductive medicine, modern IVF techniques and a human approach that makes all the difference.
Our treating physicians, Dr. Maria Oikonomou and Dr. Makis Papadopoulos, are officially specialised in infertility and gynaecological endocrinology, offering personalised protocols for each case. We collaborate with leading units, such as the Institute of Life and the IAMA Clinic, utilising cutting-edge technology, with transparent prices, high success rates and a holistic approach.
We collaborate with leading units, such as the Institute of Life and the IAMA Clinic, utilising cutting-edge technology, with transparent prices, high success rates and holistic support throughout your journey.
FertUlity means reliability, expertise and human interest. Because life begins with the right choice.
