What additional tests are required for ICSI?
During ICSI preparation, additional tests are often necessary—especially when male infertility is suspected. At FertUlity, the process begins with a detailed semen analysis (spermogram) to evaluate sperm count, motility, and morphology. In some cases, a DNA fragmentation test may be performed to identify potential issues in the genetic material. If sperm count is very low or entirely absent, genetic testing may be recommended to detect chromosomal abnormalities. Simultaneously, the woman undergoes blood and hormonal tests (AMH, TSH, FSH) to develop a fully personalized treatment plan.
Will all eggs be fertilized during ICSI?
No, ICSI does not guarantee that all retrieved eggs will be fertilized. Only mature eggs are suitable for sperm injection. On average, 75–80% of retrieved eggs are mature enough to proceed with ICSI. The remaining ones are either immature or non-viable and cannot be used. Even among the mature eggs, fertilization depends on various factors, such as sperm quality and egg condition. At FertUlity, eggs are selected and processed with exceptional precision to increase the chances of successful fertilization.
Is genetic testing recommended before ICSI?
Preconception genetic testing can be a valuable tool in certain cases, particularly when there is severe male infertility such as azoospermia or extremely low sperm count. At FertUlity, we consider genetic screening when there is a heightened risk of transmitting genetic abnormalities. This may include chromosomal analysis (e.g., Klinefelter syndrome) or gene mutation testing. Combined with preimplantation genetic testing (PGT), couples can make informed choices to safeguard their future child’s health.
How does ICSI affect embryo quality?
ICSI has not been shown to negatively affect embryo quality. On the contrary, in cases of male infertility, it offers a controlled fertilization environment that increases the chances of developing viable embryos. When high-quality eggs and well-selected sperm are used, the resulting embryos develop comparably to those created via conventional IVF. At FertUlity, we implement optimized embryo culture protocols to ensure top-tier embryological outcomes.
What happens if fertilization fails after ICSI?
Complete fertilization failure after ICSI is rare, occurring in fewer than 5% of cases. However, if it does happen, the cycle is usually canceled, and the medical team reviews all parameters. Partial failure, where only a few eggs are fertilized, is more common. At FertUlity, we place great emphasis on identifying the causes and making adjustments in future attempts—such as modifying stimulation protocols, improving sperm processing, or conducting further diagnostic testing.
Are there age restrictions for ICSI treatment?
ICSI as a technique has no strict age limits, but a woman’s age significantly influences success rates. After age 40, both egg quality and quantity typically decline, directly impacting implantation and pregnancy outcomes. Greek law (as of 2022) permits IVF treatment up to age 54 under specific conditions. At FertUlity, we carefully assess each woman’s medical and hormonal profile to provide realistic expectations and responsible guidance before treatment begins.
Can ICSI be performed with frozen eggs or sperm?
Yes, ICSI is fully compatible with the use of frozen eggs or sperm. In fact, it is often the preferred method—especially for previously frozen eggs. Cryopreservation can harden the outer shell of the egg, making natural sperm penetration difficult. With ICSI, the embryologist directly injects the sperm into the egg, bypassing this barrier. At FertUlity, we use high-precision protocols for fertilizing frozen gametes to ensure optimal success conditions.
How long does the ICSI process take?
ICSI is part of a complete IVF cycle that typically lasts 4 to 6 weeks. Ovarian stimulation takes around 10–12 days, followed by egg retrieval, sperm injection (ICSI), and embryo culture for 3–5 days. Embryo transfer is then performed. The ICSI procedure itself—injecting sperm into eggs—takes a few hours in the lab, but medical supervision and support continue throughout the entire cycle.
What is the cost of ICSI?
At FertUlity, we believe access to effective treatment should not be limited by cost. That’s why ICSI is included in all our IVF protocols at no additional charge. We offer fully transparent treatment plans so couples can focus on care and hope, not expenses. The total cost may vary depending on the need for genetic testing (PGT) or additional evaluations. Our team is always available to provide personalized financial guidance.
Are babies born via IVF and ICSI healthy?
Babies conceived through ICSI are generally just as healthy as those conceived naturally. Some studies suggest a slightly higher chance of preterm birth or low birth weight, but the vast majority of ICSI-conceived children are completely healthy. At FertUlity, we apply rigorous scientific protocols and personalized monitoring to provide parents with confidence and high-quality care from conception to birth.
Does ICSI increase the risk of autism?
The potential link between ICSI and autism has been explored in several studies. While some findings show a slightly higher prevalence of autism spectrum disorders among children conceived via assisted reproductive technologies, the evidence is not conclusive. Many other factors—such as parental age, genetics, and underlying health conditions—play a more significant role. At FertUlity, we address parents’ concerns with scientific integrity, offering evidence-based guidance at every step.
Can ICSI cause chromosomal abnormalities?
When performed with proper criteria and scientific accuracy, ICSI does not significantly increase the risk of chromosomal abnormalities. Since the technique bypasses natural sperm selection, there’s a theoretical chance of using sperm with hidden genetic defects. That’s why at FertUlity, we thoroughly assess sperm quality prior to use and recommend preimplantation genetic testing (PGT) when indicated. This ensures that only healthy embryos are transferred, offering maximum safety for the couple.
Can ICSI damage the embryos?
ICSI is a highly delicate and precise technique, but when performed by skilled embryologists—like those at FertUlity—the risk of damage is minimal. There’s a small theoretical possibility of injuring the egg during sperm injection, but this is rare. Our embryologists use cutting-edge micromanipulation tools in a meticulously controlled environment to protect each egg and embryo, ensuring optimal development conditions.
